Frequently asked question: What exactly does hydroxycarbamide (Hydrea © or Siklos©) do?

Hydroxycarbarmide intervenes in the production of blood cells in the bone marrow. As blood production in the bone marrow is suppressed, the bone marrow creates HbF (fetal hemoglobin) again instead of HbS. When HbF levels rise, the HbSS red blood cell percentage drops, which often leads to the disease being less severe. Aside from that, it also inhibits the production of white blood cells and platelets, causing the number of cells in the bloodstream to fall, which means less chance of sickle cell crises. It also makes red blood cells less quick to clot together or stick to the vascular wall.

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