Frequently asked question: What exactly has gone wrong in Graves' disease?

If you have Graves' disease, your body makes antibodies against your TSH receptors. The TSH receptors are located in the thyroid gland and bind to TSH (thyroid-stimulating hormone). This binding process initiates thyroid hormone production. TSH fits perfectly into the receptor, like a key in a lock. The antibody against the TSH receptor (TSI, thyroid-stimulating immunoglobulin) also fits perfectly into the receptor and can also stimulate the thyroid to synthesize and secrete more thyroid hormone (T4 and T3).

Relevant medical information